1895, a medical hybrid coined from Latin-based quadri- "four" + -plegia, as in paraplegia, ultimately from Greek plege "stroke," from root of plēssein "to strike" (from PIE root *plak- (2) "to strike"). A correct, all-Greek formation would be *tetraplegia.
quadrilateral
quadriliteral
quadrille
quadrillion
quadripartite
quadriplegia
quadriplegic
quadrivium
quadroon
quadru-
quadruped