1640s, "full of regret," from regret + -ful. Regretfully, properly "with regret," incorrectly used in place of regrettably "it is to be regretted that; calling for regret" at least since 1965. "A regrettable use, prob. after HOPEFULLY adv.2" [OED].
felt regretful over his vanished youth
regretful over mistakes she had made
regolith
regress
regression
regressive
regret
regretful
regrettable
regroup
regrowth
regular
regularity