"capacity for understanding, perceptive power," 1816, from up (adv.) + take (v.). Compare Middle English verb uptake "to pick or take up" (c. 1300). Meaning "pipe leading up from the smoke box of a steam boiler to the chimney" is from 1839.
they developed paper napkins with a greater uptake of liquids
upstate
upstream
upsurge
upswing
upsy-daisy
uptake
uptick
uptight
up-to-date
uptown
upturn