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uptown (adv.)

1802, "to or in the higher or upper portion of a town," from up (adv.) + town (n.). As an adjective from 1838. As this usually was the residential portion of a town (especially a port) the word had overtones of "residential quarter" as opposed to "commercial and industrial district." As a noun from 1946, often meaning "more prosperous area of town."

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Definitions of uptown from WordNet
1
uptown (n.)
a residential part of town away from the central commercial district;
2
uptown (adv.)
toward or in the upper part of town;
3
uptown (adj.)
of or located in the upper part of a town;
uptown residential areas
From wordnet.princeton.edu