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MYXOEDEMA (or athyrea)

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Originally appearing in Volume V19, Page 144 of the 1911 Encyclopedia Britannica.
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MYXOEDEMA (or athyrea) , the medical See also:term for a constitutional disease (see METABOLIC DISEASES) due to the degeneration of the See also:thyroid gland, and occurring in adults; it may be contrasted with See also:cretinism, which is a See also:condition appearing in See also:early childhood. There are two forms, myxoedema proper and operative myxoedema (cachexia slrumipriva). (1) Myxoedema has been termed " See also:Gull's Disease" from See also:Sir See also:William Gull's observations in 1873. See also:Women are more often the victims than men, in a ratio of 6 to 1. It frequently affects members of the same See also:family and may be transmitted through the See also:mother, and it has been observed sometimes to follow exophthalmic See also:goitre. The symptoms are a marked increase in bulk and See also:weight of the See also:body, puffy See also:appearance of skin which does not See also:pit on pressure, the See also:line of the features becoming obliterated and getting coarse and broad, the lips thick and nostrils enlarged, with loss of See also:hair, subnormal temperature and marked See also:mental changes. There is striking slowness of thought and See also:action, the memory becomes defective, and the patient becomes irritable and suspicious. In some instances the condition progresses to that of dementia. The thyroid gland itself is diminished in See also:size, and may become completely atrophied and converted into a fibrous See also:mass. The untreated disease is progressive, but the course is slow and the symptoms may extend over 12 to 15 years, See also:death from asthenia or See also:tuberculosis being the most frequent ending. (2) Symptoms similar to the above me y follow See also:complete removal of the thyroid gland. Kocher of See also:Bern found that, in the See also:total removal of the gland by operation, out of 408 cases operative myxoedema occurred in 6g, but it is thought that if a small portion of the gland is See also:left, or if See also:accessory glands are See also:present, these symptoms will not develop.

The treatment of myxoedema is similar to that of cretinism.

End of Article: MYXOEDEMA (or athyrea)

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