Middle English -ik, -ick, word-forming element making adjectives, "having to do with, having the nature of, being, made of, caused by, similar to," from French -ique and directly from Latin -icus or from cognate Greek -ikos "in the manner of; pertaining to." From PIE adjective suffix *-(i)ko, which also yielded Slavic -isku, adjectival suffix indicating origin, the source of the -sky (Russian -skii) in many surnames. In chemistry, indicating a higher valence than names in -ous (first in benzoic, 1791).

In Middle English and after often spelled -ick, -ike, -ique. Variant forms in -ick (critick, ethick) were common in early Modern English and survived in English dictionaries into early 19c. This spelling was supported by Johnson but opposed by Webster, who prevailed.

word-forming element used in chemistry to coin names for simple compounds of one element with another element or radical; originally abstracted from oxide, which was the first so classified, in which the -ide is from acide "acid."

The suffix is really -dus (-do-), the -i- repr. the orig. or supplied stem-vowel ; it occurs without the vowel in absurdus, absurd, blandus, bland, crudus, raw (crude), etc. [Century Dictionary]