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ache (v.)

Old English acan "suffer continued pain," from Proto-Germanic *akanan, perhaps from a PIE root *ag-es- "fault, guilt," represented also in Sanskrit and Greek, which is perhaps imitative of groaning.

Originally the verb was pronounced "ake," the noun "ache" (as in speak/speech). The noun changed pronunciation to conform to the verb, but the spelling of both was changed to ache c. 1700 on a false assumption of a Greek origin (specifically Greek akhos "pain, distress," which rather is a distant relation of awe (n.)). Related: Ached; aching.

ache (n.)

"continuing pain," early 15c., æche, ece "an ache, pain," from Old English æce, from Proto-Germanic *akiz, from same source as ache (v.), which see for the unusual evolution of spelling and pronunciation.

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Definitions of ache from WordNet
1
ache (v.)
feel physical pain;
Synonyms: hurt / suffer
ache (v.)
have a desire for something or someone who is not present;
She ached for a cigarette
Synonyms: yearn / yen / pine / languish
ache (v.)
be the source of pain;
Synonyms: smart / hurt
2
ache (n.)
a dull persistent (usually moderately intense) pain;
Synonyms: aching
From wordnet.princeton.edu