by 1895, perhaps 1847, from low key in some sense relating to deep musical tone or quiet sound; see low (adj.) + key (n.1). Low key in reference to a quiet voice is attested from 1837. Also compare undertone.
a little masterpiece of low-keyed eloquence
lowermost
lowest
Lowestoft
low-grade
lowing
low-key
lowland
low-life
lowliness
lowly
low-minded