"laborious, tedious, involving much labor," 1670s, from Latin operosus "taking great pains, laborious, active, industrious," from opus (genitive operis) "work" (from PIE root *op- "to work, produce in abundance"). Related: Operosely; operoseness; operosity (1620s).
operationalize
operative
operator
operculum
operetta
operose
Ophelia
ophidian
ophidiophobia
ophio-
ophiomancy