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ISOXAZOLES

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Originally appearing in Volume V14, Page 885 of the 1911 Encyclopedia Britannica.
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ISOXAZOLES , monazole chemical compounds corresponding to See also:

furfurane, in which the -CH See also:group adjacent to the See also:oxygen See also:atom is replaced by a See also:nitrogen atom, and therefore they contain H C = N the See also:ring See also:system >O• They may be prepared HC =CH by the elimination of See also:water from the monoximes of 0-See also:diketones, 0-ketone See also:aldehydes or oxymethylene See also:ketones (L. Claisen, Ber., 1891, 24, p. 3906), the See also:general reaction proceeding according to the See also:equation R•CO•See also:CH2•CO•R+See also:H2N .OH =2H20+R•C = N HC=C-R W. See also:Dunstan and T. S. Dymond (Jour. Chem. See also:Soc., 1891, 49, p. 410) have also prepared isoxazoles by the See also:action of alkalis on nitroparaffins, but have not been able to obtain the See also:parent substance. Those isoxazoles in which the See also:carbon atom adjacent to nitrogen is substituted are See also:stable compounds, but if this is not the See also:case, rearrangement of the See also:molecule takes See also:place and nitriles are formed. The isoxazoles are feebly basic. The isoxazolones are the keto derivatives of the as yet unknown 'dihydroisoxazole, and are compounds of strongly See also:acid nature, decomposing the See also:carbonates of the alkaline See also:earth metals and forming salts with metals and with See also:ammonia.

End of Article: ISOXAZOLES

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