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SANTONIN

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Originally appearing in Volume V24, Page 195 of the 1911 Encyclopedia Britannica.
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SANTONIN , a See also:

drug used in the U.S.P. and B.P., consisting'of colourless See also:flat prisms, turning slightly yellow from the See also:action of See also:light and soluble in See also:alcohol, See also:chloroform and boiling See also:water. It is derived from santonica which is the unexpanded See also:flower-heads of See also:Artemisia maritima. The dose is 2 to 5 grs. The only B.P. preparation is the trochiscus santonini, but the preparation sodii santoninas is See also:official in the U.S.P. Santonin is an anthelmintic used to See also:poison the See also:round See also:worm Ascaris lumbricoides. It has no See also:influence on tape-See also:worms. It must be administered See also:fasting and be followed by a purgative in See also:order to expel the worm. The most convenient mode of See also:administration is in capsules. For See also:thread worms which infest the anus of See also:young See also:children, a suppository containing 2 to 3 grs. of santonin and used on alternate nights for three nights is effective. The U.S. preparation sodii santoninas is useless as a vermifuge and is used in diseased conditions of the optic See also:nerve. Even small doses of santonin cause disturbances of See also:vision, usually yellow vision or perhaps See also:green (xanthopsia or chromatopsia). The urine also turns yellow and finally See also:purple or red.

These effects usually pass off in a few days. Large doses, however, produce toxic effects, aphasia, See also:

muscular tremors and epileptiform See also:convulsions, and the disturbances of vision may go on to See also:total See also:blindness.

End of Article: SANTONIN

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