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PURPURA , in See also:pathology, a See also:general See also:term for the symptom of See also:purple-coloured spots upon the See also:surface of the See also:body, due to extravasations of See also:blood in the skin, accompanied occasionally with haemorrhages from mucous membranes. The varieties of purpura may be conveniently divided as follows: (a) toxic, following the See also:administration of certain drugs, notably See also:copaiba, See also:quinine, See also:ergot, See also:belladonna and the iodides; also following snake-bite; (b) cachectic, seen in persons suffering from such diseases as See also:tuberculosis, See also:heart disease, See also:cancer, See also:Bright's disease, See also:jaundice, as well as from certain of the infectious fevers, extravasations of the See also:kind above mentioned being not infrequently See also:present; (c) neurotic; (d) arthritic, which includes the See also:form known as " Purpura simplex," in which there may or may not be articular See also:pain, and the complaint is usually ushered in by lassitude and feverishness, followed by the See also:appearance on the surface of the body of the characteristic spots in the form of small red points scattered over the skin of the limbs and See also:trunk. The spots are not raised above the surface, and they do not disappear on pressure. Their See also:colour soon becomes deep purple or nearly See also:black; but after a few days they undergo the changes which are observed in the See also:case of an See also:ordinary bruise, passing to a See also:green and yellow See also:hue and finally disappearing. When of See also:minute See also:size they are termed "petechiae" or " stigmata," when somewhat larger " vibices," and when in patches of considerable size " ecchymoses." They may come out in fresh crops over a lengthened See also:period. Purpura rheumatica (Schonlein's disease) is a remarkable variety characterized by sore See also:throat, See also:fever and articular pains accompanied by purpuric spots and associated with urticaria and occasionally with definite nodular infiltrations. This is by many writers considered to be a See also:separate disease, but it is usually regarded as of rheumatic origin. Purpura haemorrhagica (acute haemorrhagic purpura) is a more serious form, in which, in addition to the phenomena already mentioned as affecting the skin, there is a tendency to the occurrence of See also:haemorrhage from mucous surfaces, especially from the See also:nose, but also from the mouth, lungs, See also:stomach, bowels, kidneys, &c., sometimes in large and dangerous amount. See also:Great See also:physical prostration is See also:apt to attend this form of the disease, and a fatal result some-times follows the successive haemorrhages, or is suddenly precipitated by the occurrence of an extravasation of blood into the See also:brain. (see above) by the See also:action of aqueous See also:ammonia at 15o° C. It also results instead of the expected 7-methyl-2-oxy-6-aminopurin, when 7-methyl-6-amino-2-chlorpurin is treated with dilute alkalis (E. See also:Fischer, Ber., 1898, 31, p. 542), owing to See also:ring splitting in the 1.6-position, followed by eliminating of halogen See also:acid. Thiopurins.—W. Traube (See also:Ann., 1904, 331, pp. 66 seq.) has obtained many compounds of the See also:purin See also:group by using thiourea, which is condensed with cyanacetic ester, &c., to form thiopyrimidines. Additional information and CommentsThere are no comments yet for this article.
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