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PILOCARPINE

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Originally appearing in Volume V21, Page 611 of the 1911 Encyclopedia Britannica.
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PILOCARPINE , C„H,6N2O2, an See also:

alkaloid found, together with isopilocarpine and other related compounds, in the leaves of See also:jaborandi (Pilocorpus pennatifolius). It was first isolated by E. See also:Hardy in 1875 (Ber., 8, p. 1594), and is a crystalline, very hygroscopic solid. It is a strong See also:poison. It has the properties of a monacid See also:base and contains the methylamino See also:group, .NCH3. When heated with hydrochloric See also:acid it gives isopilocarpine. Isopilocarpine was isolated in 1900 by H. A. D. See also:Jowett (Journ. Chem.

See also:

Soc. 77, p. 473), and is a colourless oil which boils at 261° C. (to mm.). It is a monacid base which is readily soluble in solutions of the See also:caustic alkalis. Jowett is of the See also:opinion that pilocarpine and isopilocarpine are stereo-isomers of the structure:— /CH•N•CH3CzH5•CH•C0\ Nl O \CH: C—CHz—CH•CH/z latter See also:kind is the only one to which the See also:term is now applied either in See also:British or See also:foreign countries. The word " See also:pilot " is not the See also:early name for the See also:man who guides or steers a See also:ship.. In Old See also:English the name is lfidman, i.e. the man who leads the way. " Pilot " does not appear in English till the 16th See also:century. The origin of the word has been much debated. Many etymologists find it in the Dutch pijloot (See also:Hexham's See also:Dictionary, 1658). This has been identified with peillood, peil-loth, See also:sounding See also:lead, cf.

See also:

German peilen, to See also:sound; the last See also:part of these words is the same as English " lead," the See also:metal; the first part, peilen, is for pegelen, to See also:mark with pegs or points for measuring, cf. pegel, See also:gauge. The New English Dictionary, on the other See also:hand, finds that the Dutch pilott, the earlier See also:form, is taken from the See also:French. The source is, therefore, to be looked for in See also:Romance See also:languages. Du Cange (See also:Gloss. Med. et Inf. See also:Lat.) gives Pedottae, defined as See also:quorum est scire intrare et exire See also:portus, a gloss on pedotte e timonieri in F. Ubaldini's edition, 164o, of I documenti d'amore by See also:Francesco da Barberino (1264-1348). It is therefore conjectured that the See also:Italian pilota is a popular conception of pedal/a, and a possible source may be found in the See also:Greek 765ov, See also:oar. In See also:England, formerly, pilots were subject to the See also:jurisdiction of the See also:lord high See also:admiral; and in the 16th century there are many instances of the See also:admiralty See also:court dealing with pilots disciplinarily as well as civilly, holding them liable in See also:damages to owners of See also:ships lost or damaged by their See also:negligence. For some consider-able See also:time throughout the See also:United See also:Kingdom the See also:appointment and See also:control of pilots have been in the hands of numerous See also:societies or corporations established at the various ports by See also:charter or See also:act of See also:Parliament, such as the Trinity Houses of See also:Deptford Strond (See also:London), See also:Kingston-upon-See also:Hull, See also:Newcastle-on-See also:Tyne, and See also:Leith, and the Society of Cinque Ports Pilots and Court of Lodemanage (now See also:extinct). These societies had jurisdiction over the pilots exercising their employment within Authorities> the limits of such ports, and in many cases made it compulsory for ships resorting thither to employ them. By degrees the London Trinity See also:House acquired a leading position, which was confirmed and extended by the See also:general Pilotage Acts passed in the 18th and 19th centuries, with the See also:object of introducing a See also:uniform See also:system throughout the See also:realm.

At the See also:

present See also:day the United Kingdom is divided into districts for the purpose of ,pilotage jurisdiction. The (London) Trinity House has jurisdiction over the London See also:district, which extends from Orfordness to See also:Dungeness, and comprises the See also:Thames and See also:Medway up to London and See also:Rochester See also:bridges; the English Channel district, comprising the See also:sea between Dungeness and the Isle of See also:Wight; , and the Trinity outport districts, which include any pilotage districts for the appointment of pilots within which no particular See also:provision is made by act of Parliament or charter, and the number of which is 40, all English and Welsh. There are 66 other districts, within which other pilotage authorities have jurisdiction. The present general pilotage See also:law is contained in the See also:Merchant See also:Shipping Acts 1894 to 1906. Pilotage authorities are defined as bodies or persons authorized to appoint or license pilots, or to See also:fix and alter rates of pilotage or to exercise any jurisdiction in respect of pilotage. They are subject to the control of the See also:Board of See also:Trade as the supreme See also:mercantile marine authority. Those bodies, however, which existed at the time of the passing of the act retain their See also:powers and jurisdiction, so far as is consistent with it. The board has See also:power to appoint a new pilotage authority in any See also:area where there is none, and to include a new area where there is none within an already existing one (but in either See also:case pilotage cannot be made compulsory), or to See also:transfer pilotage jurisdiction over a See also:port other than that where the pilotage authority for that port resides, from that pilotage authority to the See also:harbour or other See also:local authority for that port, or to the Trinity House, or to a new authority; and the board has all powers necessary to effectuate such transfer and constitute the new authority.

End of Article: PILOCARPINE

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